Diverse Flavonoids from the Roots of Indigofera stachyodes. Issue 10 (26th September 2022)

• Record Type: Journal Article
• Authors: Lou, Huayong; Liu, Hanfei; Wang, Huan; Zhao, Yumin; Huang, Lei; Fu, Jian; Hao, Xiaojiang; Pan, Weidong
• Is Part Of: Chemistry & biodiversity. Volume 19:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-26
• Subjects: roots of Indigofera stachyodes -- flavonoids -- ECD; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202200676
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Three new flavonoids, 4′‐ O ‐ β ‐D‐glucopyranosyl‐2 S, 3 R ‐3, 7‐dihydroxy‐3′‐methoxyflavan (1 ), (3 R )‐7, 4′‐dihydroxy‐5, 3′‐methoxychalcone (2 ), (3 S )‐7, 2′, 3′‐trihydroxy‐6, 4′‐dimethoxylisoflavan (3 ), and one new natural occurring product, (3 S )‐6, 2′, 3′‐trihydroxy‐7, 4′‐dimethoxylisoflavan (4 ), together with eleven known ones (5 –15 ), were isolated from the roots of Indigofera stachyodes . The structures of these compounds were confirmed by UV, IR, MS, and NMR spectroscopic analysis. The absolute configurations of new compounds were elucidated by ECD spectra and chemical method. All the isolated flavonoids were screened for their antioxidant abilities to scavenge DPPH and ABTS + . As results, compounds 2 –4, 10, and 15 exhibited remarkable scavenging activity against both ABTS + and DPPH, with the IC50 values less than 20 μM. In addition, compounds 1, 6 –9, and 13 exhibited potential antioxidant scavenging activities, IC50 values were in the range of 17.96∼85.91 μM. Abstract :