Decreased level of plasma nesfatin-1 in rats exposed to cell phone radiation is correlated with thyroid dysfunction, oxidative stress, and apoptosis. (2nd November 2022)

• Record Type: Journal Article
• Authors: Hussien, Noha I.; Mousa, Ayman M.; Shoman, Abeer A.
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 6(2022)
• Page Start: 1486
• Page End: 1492
• Publication Date: 2022-11-02
• Subjects: Nesfatin-1 -- cell phone radiation -- thyroid function -- oxidative stress and apoptosis; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1778037
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Context: Exposure to Electomagnetic radiation fields of cell phones causes thyroid dysfunction and a previous study revealed that nesfatin-1 may affect functions of the thyroid gland. Objective: To study the role of nesfatin-1 on functions of rat's thyroid gland exposed to EMRF. Materials and methods: Thirty adult male rats were divided equally into 3 groups as group I, group II and group III. The experiment extended for 30 days then the plasma nesfatin-1 level, thyroid functions, and thyroid tissue oxidative stress were assessed. Also; histological and immunohistochemical study studies were done to evaluate structural and apoptotic changes of the thyroid gland. Results: There was a significant decrease in plasma nesfatin-1 level and thyroid functions with an increase in oxidative stress and apoptosis. Interestingly, there was a correlation between nesfatin-1 level and markers of thyroid function, oxidative stress and apoptosis. Conclusion: Nesfatin-1 plays a role in thyroid dysfunctions of rats exposed to mobile phone radiation.