High-protein diet associated with resistance training reduces cardiac TNF-α levels and up-regulates MMP-2 activity in rats. (2nd November 2022)

• Record Type: Journal Article
• Authors: Nogueira, Murilo Esteves; Sousa Neto, Ivo Vieira; Motta-Santos, Daisy; Cantuária, Ana Paula de Castro; Lima, Stella Maris de Freitas; Rezende, Taia Maria Berto; Santana, Hugo Alexandre de Paula; Petriz, Bernardo Assis; Marqueti, Rita de Cássia; Almeida, Jeeser Alves
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 6(2022)
• Page Start: 1630
• Page End: 1636
• Publication Date: 2022-11-02
• Subjects: Protein source -- resistance training -- inflammation -- exercise; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1787456
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: The consumption of high-protein diets (HPD) is associated with resistance training (RT) due to effects on metabolism. However, little is known about these effects on cardiac tissue. This study aimed to investigate effects of HPD and RT on cardiac biomarkers. 18 rats were divided into normo-protein (NPD), and HPD groups: NPD-Control, NPD-RT, HPD-Control, and HPD-RT. Interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-a), nitric oxide (NO), activity of metalloproteinase-2 (MMP-2), and vascular factor (VEGF) were analysed. RT was effective in regulating body weight, increasing strength, and reducing food consumption ( p < .05). HPD induces higher levels of interleukin 6 ( p = .0169), and lowers NO ( p < .0001). When associated with RT, the HPD decreases levels of tumour necrosis factor alpha, while enhances NO, and MMP activity ( p < .05). The association of RT with HDP decreases inflammatory parameters and indicates an enhancement in the molecular parameters of cardiac tissue.