Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis. (2nd November 2022)

• Record Type: Journal Article
• Authors: Gholamalizadeh, Maryam; Mirzaei Dahka, Samaneh; Vahid, Farhad; Bourbour, Fatemeh; Badeli, Mostafa; JavadiKooshesh, Sepehr; Mosavi Jarrahi, Seyed Alireza; Akbari, Mohammad Esmail; Azizi Tabesh, Ghasem; Montazeri, Fatemeh; Hassanpour, Ayemeh; Doaei, Saeid
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 6(2022)
• Page Start: 1421
• Page End: 1425
• Publication Date: 2022-11-02
• Subjects: The fat mass and obesity associated -- FTO -- body fat -- polymorphism; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1773861
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Studies that meet inclusion criteria were collected for the final analysis. There was significant differences in the level of BF% between different genotypes of FTO rs9939609 polymorphism, and the carriers of the A allele of FTO rs9939609 polymorphism had higher BF%. The association was significant between carriers of TT genotype compared to carriers of AA ( p = .007) and AT genotypes ( p = .04), but not between AT and AA genotypes. This study identified that the carriers of the A allele of FTO rs9939609 polymorphism have higher BF%.