Advances of engineered extracellular vesicles-based therapeutics strategy. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Komuro, Hiroaki; Aminova, Shakhlo; Lauro, Katherine; Harada, Masako
• Is Part Of: Science and technology of advanced materials. Volume 23:Issue 1(2022)
• Page Start: 655
• Page End: 681
• Publication Date: 2022-12-31
• Subjects: Extracellular vesicles -- engineered extracellular vesicles -- drug delivery -- EV therapeutics -- biomaterials; Materials -- Technological innovations -- Periodicals; 620.112
• DOI: 10.1080/14686996.2022.2133342
• Languages: English
• ISSNs: 1468-6996

Abstract

ABSTRACT: Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and lipids. They mediate intercellular communication through transporting internally packaged molecules, making them attractive therapeutics carriers. Over the last decades, a significant amount of research has implied the potential of EVs servings as drug delivery vehicles for nuclear acids, proteins, and small molecular drugs. However, several challenges remain unresolved before the clinical application of EV-based therapeutics, including lack of specificity, stability, biodistribution, storage, large-scale manufacturing, and the comprehensive analysis of EV composition. Technical development is essential to overcome these issues and enhance the pre-clinical therapeutic effects. In this review, we summarize the current advancements in EV engineering which demonstrate their therapeutic potential. GRAPHICAL ABSTRACT: uf0001