Genetic polymorphisms −137 (G > C) (rs187238) and −607 (C > A) (rs1946518) and serum level of interleukin 18 in Fars ethnic groups with metabolic syndrome in Northern Iran. (2nd November 2022)

• Record Type: Journal Article
• Authors: Aghajani, Roja; Saeidi, Mohsen; Amiriani, Taghi; Marjani, Majid; Amiriani, Amir Hossein; Akhavan Tabib, Atefeh; Marjani, Abdoljalal
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 6(2022)
• Page Start: 1596
• Page End: 1602
• Publication Date: 2022-11-02
• Subjects: Genetic polymorphism -- interleukin 18 -- Fars ethnic -- metabolic syndrome -- Iran; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1784954
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Introduction: We aimed to determine the genetic polymorphisms and serum level of interleukin 18 in Fars ethnic groups. Material and methods: 226 Fars ethnic groups were participated. The ATP III criteria were used to assess MS components. The SNPs of the IL-18 gene were determined with ARMS-PCR. Results: The GG, GC, and CC genotypes of −137 were 50%, 40%, and 10%. The CC, CA, and AA genotypes of −607 were 45%, 37%, and 18%. The GG, GC, and CC genotypes of −137 were 44.20%, 43.40%, and 12.40%, and were 55.75%, 36.28%, and 7.97% in subjects with and without MS, respectively. The CC, CA, and AA genotypes of −607 were 48.70%, 37.20%, and 14.20% and were 41.60%, 37.20%, and 21.20% in both groups, respectively. Conclusion: IL-18 gene may different in specific populations, different ethnic groups and geographic regions. The IL-18 polymorphisms might not be used as a marker of metabolic syndrome.