1, 4-Dihydropyridine: synthetic advances, medicinal and insecticidal properties. Issue 45 (12th October 2022)

• Record Type: Journal Article
• Authors: A., Parthiban; Makam, Parameshwar
• Is Part Of: RSC advances. Volume 12:Issue 45(2022)
• Page Start: 29253
• Page End: 29290
• Publication Date: 2022-10-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra04589c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : 1, 4-Dihydropyridine (1, 4-DHP) is one of the foremost notable organic scaffolds with diverse pharmaceutical applications. Abstract : 1, 4-Dihydropyridine (1, 4-DHP) is one of the foremost notable organic scaffolds with diverse pharmaceutical applications. This study will highlight recent accomplishments in the construction of 1, 4-DHP with structural and functional modifications using multi-component one-pot and green synthetic methodologies. The various intrinsic therapeutic applications, ranging from calcium channel blocker, anti-oxidative, anticancer, anti-inflammatory, anti-microbial, anti-hypertensive, anti-diabetic, anticoagulants, anti-cholinesterase, neuro-protective, and other miscellaneous activities, have been summarized with a focus on their structure–activity relationship (SAR) investigations. In addition, the insecticidal properties have been collated and discussed. Researchers in the fields of medicinal chemistry and drug development will find the summarized conclusions of this study incredibly informative, instructional, and valuable.