Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine ZnII complex. Issue 21 (29th September 2022)

• Record Type: Journal Article
• Authors: Srinarawat, Waralee; Hemstapat, Ruedee; Tawonsawatruk, Tulyapruek; Patikarnmonthon, Nisa; Hamachi, Itaru; Ojida, Akio; Wongkongkatep, Jirarut
• Is Part Of: Analyst. Volume 147:Issue 21(2022)
• Page Start: 4910
• Page End: 4918
• Publication Date: 2022-09-29
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d2an01257j
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Calcium pyrophosphate deposition disease or pseudogout is a type of chronic and painful joint arthropathy. Accurate identification of calcium pyrophosphate dihydrate (CPPD) single crystals is crucial for determining the best course of treatment. Abstract : Calcium pyrophosphate deposition disease, previously known as pseudogout, is a type of chronic and painful joint arthropathy. Accurate identification of calcium pyrophosphate dihydrate (CPPD) single crystals is crucial for determining the best course of treatment. In this study, a two-step method involving alizarin red S (ARS) and a xanthene dipicolylamine Zn II (XDZ) complex was employed for the identification of CPPD single crystals in both triclinic and monoclinic forms using a fluorescence microscope and a microplate reader. The accurate identification method proposed in this study has the potential to advance the diagnosis and treatment of patients suffering from painful gouty arthritis.