Base-promoted highly efficient synthesis of nitrile-substituted cyclopropanes via Michael-initiated ring closure. Issue 44 (6th October 2022)

• Record Type: Journal Article
• Authors: Ye, Min; Xu, Fan; Bai, Yun; Zhang, Fanglian; Wang, Wenjia; Qian, Yiping; Chen, Zhengwang
• Is Part Of: RSC advances. Volume 12:Issue 44(2022)
• Page Start: 28576
• Page End: 28579
• Publication Date: 2022-10-06
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra05393d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient base-promoted synthesis of nitrile-substituted cyclopropanes from 2-arylacetonitriles and α-bromoennitriles under mild conditions via Michael-initiated ring closure. Abstract : A convenient and efficient annulation reaction has been developed for the general synthesis of dinitrile-substituted cyclopropanes in moderate to excellent yields. A variety of 2-arylacetonitriles and α-bromoennitriles were compatible under the standard conditions. The reaction was achieved through tandem Michael-type addition followed by intramolecular cyclization. The preliminary application of this method was confirmed by the synthesis of the 2, 4-dioxo-3-azabicyclo[3.1.0]hexane scaffold.