Short-term follow-up of intestinal flora in radiation-exposed mice. (11th April 2019)

• Record Type: Journal Article
• Authors: Yamanouchi, Kanako; Tsujiguchi, Takakiyo; Sakamoto, Yamato; Ito, Koichi
• Is Part Of: Journal of radiation research. Volume 60:Number 3(2019:May)
• Page Start: 328
• Page End: 332
• Publication Date: 2019-04-11
• Subjects: intestinal flora -- Bifidobacterium -- Lactobacillus -- alimentary tract disorder; Radiology, Medical -- Periodicals; Radiobiology -- Periodicals; Radiation -- Periodicals; 616.0757
• DOI: 10.1093/jrr/rrz002
• Languages: English
• ISSNs: 0449-3060

Abstract

Abstract: Some gastrointestinal bacteria, otherwise known as the 'intestinal flora', can cause severe gastrointestinal problems, including sepsis, which are strongly linked to lifestyle-related diseases, including cardiovascular diseases. Several investigations have focused on the long-term changes in the intestinal flora associated with radiation exposure; however, the short-term effects remain unknown. In this study, we tracked the short-term changes in the intestinal flora of mice exposed to different doses of X-ray irradiation (2 Gy and 4 Gy), focusing only on the lactic acid bacteria Bifidobacterium and Lactobacillus . A decrease in the Lactobacillus abundance was detected immediately after irradiation in individuals exposed to both 2 Gy and 4 Gy irradiation. However, mice exposed to 4 Gy of irradiation showed a remarkable increase in Bifidobacterium, indicating a potential role of these bacteria in regeneration of the intestinal epithelial tissue. Studies on changes in intestinal bacteria as a result of radiation exposure are limited. Therefore, continuation of this field of research is expected to provide important fundamental insight into the mechanisms by which radiation causes damage to the intestinal tissues, contributing to the development of sepsis.