Asymptomatic uterine metastasis of breast cancer: Case report and literature review. Issue 41 (14th October 2022)

• Record Type: Journal Article
• Authors: Kong, Dechen; Dong, Xiaotong; Qin, Peiyan; Sun, Daqing; Zhang, Zhengtao; Zhang, Yan; Hao, Furong; Wang, Mingchen
• Is Part Of: Medicine. Volume 101:Issue 41(2022)
• Page Start: e31061
• Publication Date: 2022-10-14
• Subjects: asymptomatic metastasis -- breast cancer -- case report -- diagnosis -- GATA-3 -- uterus metastasis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000031061
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Rationale: Uterine metastasis from breast cancer is extremely rare. Asymptomatic patients with cervical metastases from breast cancer are rarer and more likely to be missed. We present an asymptomatic patient with breast cancer metastasized to the uterus and share opinions on diagnosing and treating for this kind of cases. Patient concerns: We present the case of a 64-year-old woman who was diagnosed with both breast cancer and uterine fibroids after examination. She had no symptoms of gynecological disease during breast cancer treatment. A positron emission tomography/computed tomography (PET/CT) scan was performed during reexamination, revealing multiple metastases of the bone throughout the body and an abnormal hypermetabolic mass in the uterus. It was later confirmed as uterine metastasis by pathology. Diagnosis: A diagnosis of metastatic breast invasive lobular carcinoma was established after a uterine curettage. Interventions and outcomes: Treatment of the uterine metastasis included systemic chemotherapy, total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH and BSO), postoperative radiotherapy, and postoperative chemotherapy. The patient eventually refused further treatment for personal reasons and died at home. Lessons: Breast cancer metastases to the uterus are very rare and further research is needed for their diagnosis and treatment. During reexamination of breast cancer patients, clinicians must be alert to metastasis to gynecologic organs. This is particularly important in hormone receptor-positive patients with asymptomatic distant metastasis.