Utility of Routine Esophageal Biopsies in Patients With Refractory Reflux Symptoms. (8th April 2021)

• Record Type: Journal Article
• Authors: Oude Nijhuis, Renske A.B.; Curvers, Wouter L.; van der Ende, Mirjam; Herregods, Thomas V.K.; Schuitenmaker, Jeroen M.; Smout, Andreas J.P.M.; Bredenoord, Albert J.
• Is Part Of: American journal of gastroenterology. Volume 116:Number 4(2021)
• Page Start: 816
• Page End: 820
• Publication Date: 2021-04-08
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000001064
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: This study aimed to assess the diagnostic yield of routine esophageal biopsies in patients with refractory reflux symptoms. METHODS: We prospectively enrolled consecutive patients referred for upper endoscopy and collected histological, clinical, and endoscopic data. RESULTS: Of the 301 included patients, 14 (4.7%) patients met the clinicopathological diagnostic definition of eosinophilic esophagitis. Presence of dysphagia, food bolus impaction, atopic background, and typical endoscopic features were the factors with the strongest association and diagnostic accuracy for eosinophilic esophagitis. The diagnostic yield in patients lacking symptoms of dysphagia or endoscopic features was negligible (0% and 1.9%, respectively). DISCUSSION: Routine esophageal biopsy sampling in patients with refractory reflux symptoms has a low diagnostic yield. Esophageal biopsies should only be obtained in patients with refractory reflux symptoms who also present with dysphagia (see Visual abstract, Supplementary Digital Content 2, http://links.lww.com/AJG/B792 ).