Dietary β-carotene and vitamin A and risk of Parkinson disease: A protocol for systematic review and meta-analysis. Issue 41 (14th October 2022)

• Record Type: Journal Article
• Authors: Wu, Ling-Yu; Chen, Jing-Xin; Chen, Gui-Sheng; Gao, Hua; Huo, Jing-Hong; Pang, Yu-Fei; Gao, Qing-Han
• Is Part Of: Medicine. Volume 101:Issue 41(2022)
• Page Start: e31002
• Publication Date: 2022-10-14
• Subjects: meta-analysis -- Parkinson disease -- systematic review -- vitamin A -- β-carotene; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000031002
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Background: The beneficial effects of dietary β-carotene and vitamin A on Parkinson disease (PD) have been confirmed, but some studies have yielded questionable results. Therefore, this meta-analysis investigated the effect of dietary β-carotene and vitamin A on the risk of PD. Methods: The following databases were searched for relevant paper: PubMed, Embase, Medline, Scopus, Cochrane Library, CNKI, Wanfang Med online, and Weipu databases for the relevant paper from 1990 to March 28, 2022. The studies included were as follows: β-carotene and vitamin A intake was measured using scientifically recognized approaches, such as food frequency questionnaire (FFQ); evaluation of odds ratios using OR, RR, or HR; β-carotene and vitamin A intake for three or more quantitative categories; and PD diagnosed by a neurologist or hospital records. Results: This study included 11 studies (four cohort studies, six case–control studies, and one cross-sectional study). The high β-carotene intake was associated with a significantly lower chance of developing PD than low β-carotene intake (pooled OR = 0.83, 95%CI = 0.74‐0.94). Whereas the risk of advancement of PD was not significantly distinctive among the highest and lowest vitamin A intake (pooled OR = 1.08, 95%CI = 0.91‐1.29). Conclusions: Dietary β-carotene intake may have a protective effect against PD, whereas dietary vitamin A does not appear to have the same effect. More relevant studies are needed to include into meta-analysis in the further, as the recall bias and selection bias in retrospective and cross-sectional studies cause misclassifications in the assessment of nutrient intake.