Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis. (19th November 2022)

• Record Type: Journal Article
• Authors: Zuraski, Connor R.; Wales, Cameron; Nguyen, Cuong V.; Chan, Edward F.; Kovarik, Carrie; Seykora, John T.; Elenitsas, Rosalie; Moshiri, Ata S.
• Is Part Of: American journal of dermatopathology. Volume 44:Number 11(2022)
• Page Start: 812
• Page End: 816
• Publication Date: 2022-11-19
• Subjects: cutaneous -- ganglioneuroma -- seborrheic keratosis -- epidermal hyperplasia; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000002249
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract: Cutaneous ganglioneuromas (GNs) are exceptionally uncommon tumors, and many reported cases describe association with overlying epidermal hyperplasia that may be interpreted as seborrheic keratosis (SK) or SK-like proliferation. We report 5 cases of cutaneous GN in adult patients; all of which were discovered incidentally in the immediate vicinity of epidermal hyperplasia. A review of the literature demonstrates the current—although likely imperfect—understanding of the etiopathogenesis of both SK and GN in the skin. We explore the putative pathophysiologies of other common, well-characterized skin lesions and, taking them into account, provide rationale for the coexistence of cutaneous GN with overlying SK and SK-like epidermal changes. However, we ultimately acknowledge a dilemma of causality and, given the rarity of their co-occurrence, objectively question whether occasional cameo appearances by GN lying subjacent to SK and SK-like hyperplasia may be due merely to chance.