Correlation between synuclein gamma and angiogenesis in colon cancer. Issue 2 (December 2018)

• Record Type: Journal Article
• Authors: Elsers, Dalia A.; El-Sayed, Motaz A.; Kamel, Nermeen A.; Sayed, Zain; Rezk, Khalid; Rayan, Amal
• Is Part Of: Egyptian journal of pathology. Volume 38:Issue 2(2018)
• Page Start: 220
• Page End: 226
• Publication Date: 2018-12
• Subjects: Pathology -- Periodicals; 616.0705
• DOI: 10.1097/01.XEJ.0000552658.55957.a6
• Languages: English
• ISSNs: 1687-4277

Abstract

Abstract : Background: Colorectal cancer is one of the leading causes of death worldwide. Synuclein gamma (SNCG) is undetectable in normal tissue or benign lesions and shows high expression in cancer. This stage-specific expression suggested that this protein may be linked to the process of tumorigenesis. Endoglin (CD105), modulates angiogenesis by controlling of endothelial cell proliferation. Aim of the work: To analyze the immunohistochemical expression of SNCG in tumorigensis phases of colon cancer and its correlation with angiogensis and clincopathological features. Materials and methods: By immunohistocemical method, the expression of SNCG and endoglin was examined in studied biopsies (six normal colon biopsies as a control group, 10 adjacent nontumorous tissues, 10 adenomas, 30 adenocarcinomas, and six metastatic deposits in lymph nodes). Results: The increased expression of SNCG was significantly associated with increased mean vascular count and both increased with the transition from adenoma to carcinoma groups ( r =0.796, P <0.001). Conclusion: Here we report up-regulation of SNCG and endoglin protein expression with the transition from adenoma to carcinoma, and this indicates their interactive involvement in the pathogenesis of these tumors. Our findings offer opportunities for targeted therapy of cancer colon using SNCG inhibitors.