Detection of anti-B antibodies in a patient with A1B blood group: A case report and literature review. (October 2022)

• Record Type: Journal Article
• Authors: Youk, Hee-Jeong; Kim, Jin Seok; Kim, Hyungsuk; Hwang, Sang-Hyun; Oh, Heung-Bum; Chung, Yousun; Ko, Dae-Hyun
• Is Part Of: Transfusion and apheresis science. Volume 61:Number 5(2022)
• Publication Date: 2022-10
• Subjects: Anti-B -- ABO discrepancy -- ABO blood group -- Blood group typing; Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2022.103450
• Languages: English
• ISSNs: 1473-0502

Abstract

Abstract: ABO antibodies occur naturally and usually exist as alloantibodies. They are the most clinically significant in cases of transfusions. However, there are very few reports on auto-anti-A or B. A 58-year-old man visited our hospital for evaluation of an inguinal mass. Blood typing was performed, while preparing the patient for an excisional biopsy. Forward and reverse typing showed a typical AB and A pattern. Results of the direct antiglobulin and unexpected antibody screening tests were negative. The serum did not react with AB3 cells. The biopsy revealed a diffuse large B-cell lymphoma. After completing four cycles of R-CHOP chemotherapy, the patient achieved complete remission. There were no anti-B antibodies found on repeat ABO typing. This report shares our experience on unexpected anti-B antibody findings in a patient with an A1B blood type. To the best of our knowledge, this is the first report of anti-B antibodies in a patient with an A1B blood type in Korea.