Effects of peripheral administration of lipopolysaccharide on chronic sickness responses in TRPM8-deficient mice. (1st November 2022)

• Record Type: Journal Article
• Authors: Horikawa, Ririka; Oe, Yuzuki; Fujii, Rena; Kasuga, Rika; Yoshimura, Ryoichi; Miyata, Seiji
• Is Part Of: Neuroscience letters. Volume 790(2022)
• Publication Date: 2022-11-01
• Subjects: Neuroinflammation -- Endotoxemia -- Sickness Response -- Sepsis -- LPS; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2022.136895
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: TRPM8 KO mice show longer-lasting hypothermia by LPS administration. TRPM8 KO mice reveal longer-lasting decrease in motor activity by LPS treatment. TRPM8 KO mice exhibit longer-lasting decline in food intake by LPS treatment. TRPM8 KO mice show longer-lasting decrease of leucocyte number by LPS treatment. Abstract: Transient receptor potential melastatin 8 (TRPM8) is a cold-sensing thermoreceptor cation channel; however, its functional role in endotoxin-induced neuroinflammation remains unclear. In the present study, we investigated chronic sickness responses in TRPM8 knockout (KO) mice during lipopolysaccharide (LPS)-induced sepsis. The intraperitoneal administration of 5 mg/kg LPS generated longer-lasting hypothermia in TRPM8 KO mice than in wild-type (WT) mice. TRPM8 KO mice also exhibited longer-lasting declines in locomotor activity, body weight, and food and water intakes than WT mice upon LPS administration. In addition, LPS-induced decreases in the numbers of leucocytes and lymphocytes that persisted for a longer time in TRPM8 KO mice than in WT mice. The present results indicate TRPM8 attenuated chronic sickness responses in endotoxin-induced sepsis.