The Use of ADSCs as a Treatment for Chronic Stroke. Issue 4 (May 2014)

• Record Type: Journal Article
• Authors: Chan, Tzu-Min; Harn, Horng-Jyh; Lin, Hui-Ping; Chiu, Shao-Chih; Lin, Po-Cheng; Wang, Hsin-I; Ho, Li-Ing; Chuu, Chih-Pin; Chiou, Tzyy-Wen; Hsieh, An-Cheng; Chen, Yu-Wen; Ho, Wen-Yu; Lin, Shinn-Zong
• Is Part Of: Cell transplantation. Volume 23:Issue 4/5(2014)
• Page Start: 541
• Page End: 547
• Publication Date: 2014-05
• Subjects: Cerebrovascular -- Chronic stroke -- Adipose tissue-derived stem cells (ADSCs) -- Ischemic -- Hemorrhagic -- Angiogenesis -- Gliosis -- Neurotrophic factors; Cell transplantation -- Periodicals; Cell Transplantation; Cell transplantation; Electronic journals; Periodicals; Periodicals; 571.638
• DOI: 10.3727/096368914X678409
• Languages: English
• ISSNs: 0963-6897

Abstract

Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagicinduced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure.