Advances in the development of biodegradable coronary stents: A translational perspective. (December 2022)

• Record Type: Journal Article
• Authors: Zong, Jiabin; He, Quanwei; Liu, Yuxiao; Qiu, Min; Wu, Jiehong; Hu, Bo
• Is Part Of: Materials today bio. Volume 16(2022)
• Publication Date: 2022-12
• Subjects: Cardiovascular scaffolds -- Translational research -- In-stent restenosis -- Bioresorbable stents -- Stent optimization; Ag silver -- Ag+ silver ions -- AMS absorbable metal stent -- Au gold -- BDMS biodegradable metallic stent -- BDPS biodegradable polymeric stent -- BMS bare-metal stent -- BNL base neo-intimal length -- BRS bioresorbable stent -- Cl chloride -- Cl− chloride ions -- CS chitosan -- Cu copper -- CADs coronary artery diseases -- DAPT dual anti-platelet therapy -- DES drug-eluting stent -- DREAMS drug-eluting absorbable metal scaffold -- EC endothelial cell -- ECAP equal-channel angular pressure -- EDM energy dispersive spectroscopy -- EEM external elastic membrane -- EL elongation to fracture -- Fe iron -- Fe2+ ferrous ions -- Fe–O iron oxide -- GO graphene oxide -- H+ hydrogen ions -- HA hyaluronic acid -- HUVECs human umbilical vein endothelial cells -- ISR in-stent restenosis -- IVUS intravascular ultrasonography -- JDBM JiaoDa BioMg -- LDH layered double-hydroxide -- LLL late lumen loss -- LOI lumen occlusion index -- LST late stent thrombosis -- MACE major adverse cardiac event -- MAO micro-arc oxidation -- Mg magnesium -- Mg2+ magnesium ions -- MgF2 magnesium fluoride -- MgO magnesium oxide -- micro-CT micro-computerized tomography -- Mn manganese -- MPS metal-polymer composite stent -- MRI magnetic resonance imaging -- N nitrogen -- NA neo-intimal area -- OCT optical coherence tomography -- OH− hydroxyl radicals -- P phosphorus -- PCI percutaneous coronary intervention -- PCL polycaprolactone -- Pd palladium -- PDA polydopamine -- PDLLA poly-D, L-lactic acid -- PGDA poly(glycerol-dodecanoate) acrylate -- PIIID plasma immersion ion implantation and deposition -- PLA polylactic acid -- PLGA poly-lactic-co-glycolide -- PLLA poly-L-lactide acid -- PM powder metallurgy -- Pt platinum -- PTA percutaneous transluminal angioplasty -- SEM scanning electron microscopy -- SES sirolimus-eluting stent -- SMMs shape-memory materials -- SMPs shape-memory polymers -- ST stent thrombosis -- STEMI ST-segment-elevation myocardial infarction -- Ta tantalum -- Tg glass transition temperature -- TiO2 titanium dioxide -- TLF target lesion failure -- TLR target lesion revascularization -- UTS ultimate tensile strength -- VGs vein grafts -- VSMCs vascular smooth muscle cells -- WLT wire lumen thickness -- YS yield strength -- Zn zinc -- Zn2+ zinc ions; Materials science -- Periodicals; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 620.1
• DOI: 10.1016/j.mtbio.2022.100368
• Languages: English
• ISSNs: 2590-0064

Abstract

Abstract: Implantation of cardiovascular stents is an important therapeutic method to treat coronary artery diseases. Bare-metal and drug-eluting stents show promising clinical outcomes, however, their permanent presence may create complications. In recent years, numerous preclinical and clinical trials have evaluated the properties of bioresorbable stents, including polymer and magnesium-based stents. Three-dimensional (3D) printed-shape-memory polymeric materials enable the self-deployment of stents and provide a novel approach for individualized treatment. Novel bioresorbable metallic stents such as iron- and zinc-based stents have also been investigated and refined. However, the development of novel bioresorbable stents accompanied by clinical translation remains time-consuming and challenging. This review comprehensively summarizes the development of bioresorbable stents based on their preclinical/clinical trials and highlights translational research as well as novel technologies for stents (e.g., bioresorbable electronic stents integrated with biosensors). These findings are expected to inspire the design of novel stents and optimization approaches to improve the efficacy of treatments for cardiovascular diseases. Graphical abstract: Image 1 Highlights: Bioresorbable stents can overcome the limitations of non-degradable stents. 3D printing of shape-memory polymeric stents can lead to better clinical outcomes. Advances in Mg-, Fe- and Zn-based stents from a translational perspective. Electronic stents integrated with biosensors can covey stent status in real time. Development in the assessment of stent performance in vivo.