Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma. (December 2022)

• Record Type: Journal Article
• Authors: Men, Xiaoju; Geng, Xiaorui; Zhang, Zhe; Chen, Haobin; Du, Meng; Chen, Zhiyi; Liu, Gang; Wu, Changfeng; Yuan, Zhen
• Is Part Of: Materials today bio. Volume 16(2022)
• Publication Date: 2022-12
• Subjects: Cell membrane coated nanoparticles -- Second near-infrared imaging -- Conjugated polymers -- Polymer dots -- Brain tumor; Materials science -- Periodicals; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 620.1
• DOI: 10.1016/j.mtbio.2022.100383
• Languages: English
• ISSNs: 2590-0064

Abstract

Abstract: Glioma with very short medium survival time consists of 80% of primary malignant types of brain tumors. The unique microenvironment such as the existence of the blood-brain barrier (BBB) makes the glioma theranostics exhibit low sensitivity in diagnosis, a poor prognosis and low treatment efficacy. Therefore, the development of multifunctional nanoplatform that can cross BBB and target the glioma is essential for the high-sensitivity detection and ablation of cancer cells. In this study, C6 cell membrane-coated conjugated polymer dots (Pdots-C6) were constructed for targeted glioma tumor detection. As a new kind of biomimetic and biocompatible nanoprobes, Pdots-C6 preserve the complex biological functions of natural cell membranes while possessing physicochemical properties for NIR-II fluorescence imaging of glioma. After encapsulating C6 cell membrane on the surface of conjugated Pdots, Pdots-C6 exhibited the most favorable specific targeting capabilities in vitro and in vivo. In particular, this pilot study demonstrates that biomimetic nanoparticles offer a potential tool to enhance specific targeting to the brain, hence improving glioma tumor detection accuracy. Graphical abstract: Image 1