Research progress of stem cell therapy for endometrial injury. (December 2022)

• Record Type: Journal Article
• Authors: Cen, Juan; Zhang, Yichen; Bai, Yindu; Ma, Shenqian; Zhang, Chuan; Jin, Lin; Duan, Shaofeng; Du, Yanan; Guo, Yuqi
• Is Part Of: Materials today bio. Volume 16(2022)
• Publication Date: 2022-12
• Subjects: IUA -- Stem cell therapy -- Endometrial injury -- Scaffold material -- Hydrogel; Materials science -- Periodicals; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 620.1
• DOI: 10.1016/j.mtbio.2022.100389
• Languages: English
• ISSNs: 2590-0064

Abstract

Abstract: Endometrial damage is an important factor leading to infertility and traditional conventional treatments have limited efficacy. As an emerging technology in recent years, stem cell therapy has provided new hope for the treatment of this disease. By comparing the advantages of stem cells from different sources, it is believed that menstrual blood endometrial stem cells have a good application prospect as a new source of stem cells. However, the clinical utility of stem cells is still limited by issues such as colonization rates, long-term efficacy, tumor formation, and storage and transportation. This paper summarizes the mechanism by which stem cells repair endometrial damage and clarifies the material basis of their effects from four aspects: replacement of damaged sites, paracrine effects, interaction with growth factors, and other new targets. According to the pathological characteristics and treatment requirements of intrauterine adhesion (IUA), the research work to solve the above problems from the aspects of functional bioscaffold preparation and multi-functional platform construction is also summarized. From the perspective of scaffold materials and component functions, this review will provide a reference for comprehensively optimizing the clinical application of stem cells. Graphical abstract: Image 1