Incidental findings in low dose CT lung cancer screening of high-risk smokers: Results from the Manchester lung Health Check pilot. (November 2022)

• Record Type: Journal Article
• Authors: Bradley, P.; Bola, B.M.; Balata, H; Sharman, A.; Booton, R.; Crosbie, P.A.J.
• Is Part Of: Lung cancer. Volume 173(2022)
• Page Start: 1
• Page End: 4
• Publication Date: 2022-11
• Subjects: CAC coronary artery calcification -- IF incidental finding -- LDCT low dose computed tomography -- LHC lung health check -- NELSON NEderlands–Leuvens Longkanker Screenings ONderzoek trial -- NLST National Lung Screening Trial -- TLHC Targeted Lung Health Checks programme; Lung cancer screening -- Computed tomography -- Incidental findings -- Screening harms; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2022.08.017
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: The clinical significance of incidental findings in screening is poorly understood. Individuals at risk of lung cancer are also at higher risk of other pathologies. In this pilot (n = 1, 409), 11.4 % had incidental findings, including 5 malignancies. Cost-effectiveness implications should be considered during screening implementation. Abstract: Here we report the prevalence of incidental findings (IF) in the Manchester Lung Health Check pilot, which delivered mobile low-dose CT targeted lung cancer screening. 187 IFs were reported in 158 participants (11.2 % of individuals screened; n = 1, 409). 101 IFs in 90 participants (6.4 %) were concerning for extra-pulmonary malignancy. IFs resulted in 118 imaging studies, 20 invasive investigations, and 106 new diagnoses, including 5 malignancies (0.35 %). Clinical management of IFs required 84 specialist reviews (6.0 %), 34 medication changes (2.4 %) and 10 interventional treatments (0.71 %). Lung cancer screening detects clinically relevant IFs but further research is needed to better understand the potential benefits and harms of such findings to participants.