Early liver steatosis in children with pediatric Huntington disease and highly expanded CAG mutations. (October 2022)

• Record Type: Journal Article
• Authors: Squitieri, Ferdinando; Monti, Lidia; Graziola, Federica; Colafati, Giovanna Stefania; Sabatini, Umberto
• Is Part Of: Parkinsonism & related disorders. Volume 103(2022)
• Page Start: 102
• Page End: 104
• Publication Date: 2022-10
• Subjects: Paediatric huntington disease -- Childhood huntington disease -- Liver -- Steatosis -- ARF; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2022.08.027
• Languages: English
• ISSNs: 1353-8020

Abstract

Highlights: Pediatric Huntington disease (PHD) with Highly Expanded (HE) CAG mutations affects brain and peripheral organs. The liver is one affected peripheral organ showing steatosis in HE-PHD. Higher the mutation size in HE-PHD, earlier the liver steatosis in childhood HD life.