Pathogenetic Role for Early Focal Macrophage Infiltration in a Pig Model of Arteriovenous Fistula (AVF) Stenosis. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Roy-Chaudhury, Prabir; Khan, Rao; Campos, Begoña; Wang, Yang; Kurian, Michelle; Lee, Timmy; Arend, Lois; Munda, Rino
• Is Part Of: Journal of vascular access. Volume 15:Issue 1(2014)
• Page Start: 25
• Page End: 28
• Publication Date: 2014-01
• Subjects: Arteriovenous fistula -- Stenosis -- Macrophage -- Infiltration -- Pig; Arterial catheterization -- Periodicals; Intravenous catheterization -- Periodicals; 612.13
• DOI: 10.5301/jva.5000151
• Languages: English
• ISSNs: 1129-7298

Abstract

Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.