High-refined carbohydrate diet alters different metabolic functions in female rats. (1st December 2022)

• Record Type: Journal Article
• Authors: Zanol, Jordana F.; Niño, Oscar M.S.; da Costa, Charles S.; Zimerman, Jeanini; Silva, Natalia P.; Oliveira, Thalita M.; Maas, Edgar M.S.W.D.; dos Santos, Flávia C.F.; Miranda-Alves, Leandro; Graceli, Jones B.
• Is Part Of: Molecular and cellular endocrinology. Volume 558(2022)
• Publication Date: 2022-12-01
• Subjects: High-refined carbohydrate diet -- Adipose tissue -- Pancreas -- Liver -- Skeletal muscle -- Thyroid gland; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2022.111774
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: A diet containing refined carbohydrate (HCD) caused obesity and white adipose tissue (WAT) abnormalities, but it is unclear if HCD is linked with other metabolic dysfunctions in female models. Thus, we assessed whether HCD results in WAT, pancreas, liver, skeletal muscle (SM) and thyroid (TH) abnormalities in female rats. Female rats were fed with HCD for 15 days and metabolic morphophysiology, inflammation, oxidative stress (OS), and fibrosis markers were assessed. HCD rats presented large adipocytes, hyperleptinemia, and WAT OS. HCD caused irregular glucose metabolism, low insulin levels, and large pancreatic isle. Granulomas, reduced glycogen, and OS were observed in HCD livers. HCD caused hypertrophy and increased in glycogen in SM. HCD caused irregular TH morphophysiology, reduced colloid area and high T3 levels. In all selected tissues, inflammation and fibrosis were observed in HCD rats. Collectively, these data suggest that the HCD impairs metabolic function linked with irregularities in WAT, pancreas, liver, SM and TH in female rats. Graphical abstract: Image 1 Highlights: High-refined carbohydrate diet (HCD) induced obesity in female rats. HCD induced inflammation in white adipose tissue (WAT), pancreas, liver, thyroid, and muscle. Obese female rats developed hyperleptinemia and irregular glucose metabolism. Obese female rats developed abnormal thyroid gland function. WAT inflammation was linked with pancreas, liver, muscle and brown fat fibrosis.