Estimation of the Toxicity of Silver Nanoparticles by Using Planarian Flatworms. Issue 1 (March 2014)

• Record Type: Journal Article
• Authors: Kustov, Leonid; Tiras, Kharlampii; Al-Abed, Souhail; Golovina, Natalia; Ananyan, Mikhail
• Is Part Of: ATLA. Volume 42:Issue 1(2014)
• Page Start: 51
• Page End: 58
• Publication Date: 2014-03
• Subjects: ecotoxicity -- flatworm -- hydrobionts -- nanotoxicity -- planaria -- silver nanoparticles; Laboratory animals -- Periodicals; 616.0273
• DOI: 10.1177/026119291404200108
• Languages: English
• ISSNs: 0261-1929

Abstract

The regeneration of planarian flatworms — specifically, changes to the area of the regeneration bud (blastema) after surgical dissection — was proposed for use as a robust tool for estimating the toxicity of silver nanoparticles. The use of Planaria species, due to their unique regenerative capacity, could result in a reduction in the use of more-traditional laboratory animals for toxicity testing. With our novel approach, silver nanoparticles were found to be moderately toxic to the planarian, Girardia tigrina .