Adherence to Life's simple 7 is associated with better carotid properties. (November 2022)

• Record Type: Journal Article
• Authors: Nève, Gilles; Komulainen, Pirjo; Savonen, Kai; Hassinen, Maija; Männikkö, Reija; Infanger, Denis; Schmidt-Trucksäss, Arno; Rauramaa, Rainer
• Is Part Of: Atherosclerosis. Volume 360(2022)
• Page Start: 21
• Page End: 26
• Publication Date: 2022-11
• Subjects: Cardiovascular health score -- Carotid lumen diameter -- Carotid intima-media thickness -- Carotid distensibility -- Lifestyle; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2022.09.010
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Cardiovascular health scores have emerged as a simple way to assess the risk to suffer from a cardiovascular disease. The American Heart Association's Life's Simple 7 constitutes of modifiable lifestyle factors to reduce cardiovascular risk. Its association with carotid properties is yet inconclusive. The aim of this study is to determine the association between the adherence to Life's Simple 7 and carotid properties in middle-aged to elderly Finns. Methods: A representative sample of Finnish men and women aged 55–74 years was included in the present study. Carotid intima-media thickness (cIMT), lumen diameter (cLD), and carotid distensibility were measured by transcutaneous ultrasound using state-of-the-art wall contour detection techniques. The Life's Simple 7 cardiovascular health score was calculated using seven categories (body mass index, cholesterol, systolic blood pressure, fasting plasma glucose, smoking status, physical activity, and diet). In accordance to the American Heart Association, for each category, an ideal score was given 2 points, intermediate scores 1 point, and poor scores 0 points. Results: In total, 1400 (49.4% male) subjects were included in the analyses. After adjusting for age and sex, we found that subjects with a an ideal cardiovascular health score had lower cLD than those with an intermediate score (−0.21 mm, 95% CI: 0.37 to −0.05 mm, p= 0.005) and a poor score (−0.39 mm, 95% CI: 0.65 to −0.12 mm, p= 0.001). Similarly, subjects with an ideal health score had higher carotid distensibility than those with an intermediate score (0.0032 1/kPa, 95% CI: 0.009–0.0055 1/kPa, p= 0.002) and a poor score (0.0018 1/kPa, 95% CI: 0.0005–0.0032 1/kPa, p= 0.004). We found no differences regarding cIMT. Conclusions: In middle-aged to elderly Finns, higher adherence to the Life's Simple 7 is associated with lower cLD and higher distensibility, but not with cIMT. Adherence to healthy lifestyle habits is therefore associated with better carotid structure and carotid function in middle-aged to elderly Finns. Graphical abstract: Image 1 Highlights: Adherence to the Life's Simple 7 is associated with lower carotid lumen diameter. Higher cardiovascular health is linked with higher carotid distensibility. Even reaching some lifestyle goals protects carotid structure and function.