Two new physalins from Physalis alkekengi L. var. franchetii (Mast.) Makino. Issue 20 (13th October 2022)

• Record Type: Journal Article
• Authors: Sun, Jia-Min; He, Ji-Xiang; Huang, Min; Hu, Hui-Xin; Xu, Lin-Tao; Fang, Kai-Li; Wang, Xiao-Ning; Shen, Tao
• Is Part Of: Natural product research. Volume 36:Issue 20(2022)
• Page Start: 5206
• Page End: 5212
• Publication Date: 2022-10-13
• Subjects: Physalins -- Physalis alkekengi L. var. franchetii (Mast.) Makino -- 5-deoxy-4-dehydrophysalin IX -- 7α-hydroxy-5-deoxy-4-dehydrophysalin IX; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1924713
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new physalins, 7α-hydroxy-5-deoxy-4-dehydrophysalin IX (1 ) and 5-deoxy-4-dehydrophysalin IX (2 ), together with six known compounds, luteolin (3 ), luteolin-7- O -glucoside (4 ), neoechinulin A (5 ), 3-(4-hydroxy-3-methoxyphenyl)- N -(4-methylphenyl)-2-propenamide (6 ), physalin D (7 ) and blumenol A (8 ) were isolated from Physalis alkekengi L. var. franchetii (Mast.) Makino. Their structures were elucidated by NMR spectroscopic analysis, HR-ESI-MS, X-ray crystallographic data analysis and comparison with the known compounds. Among them, compounds 5 and 6 were isolated from the genus Physalis for the first time. Compound 1 exhibited weak NAD(P)H: quinone reductase (QR) inducing activity. Graphical Abstract: UF0001