Elevated Levels of Endoglin, Endostatin, FGF-α, HGF, and Thrombospondin-2 in Aqueous Humor of nAMD Patients. (4th July 2022)

• Record Type: Journal Article
• Authors: Chen, Zhiqing; Chen, Kailin; Li, Jinyu; Shen, Junhui; Xu, Wen
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 5(2022)
• Page Start: 1092
• Page End: 1098
• Publication Date: 2022-07-04
• Subjects: Neovascular age-related macular degeneration -- aqueous humor -- cytokines -- inflammation -- conbercept -- anti-VEGF; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1869785
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: to explore the aqueous cytokine profiles in nAMD patients before and after conbercept therapy. Methods: aqueous levels of 17 cytokines were detected in 20 treatment-naïve nAMD eyes and 20 age- and sex-matched age-related cataract (ARC) eyes. All of the nAMD patients received three intravitreal injections of conbercept. The central macular thickness (CMT) and maximum retinal thickness-3 mm (MRT-3 mm) were measured by SD-OCT. Fundus fluorescein angiography (FA) was used to measure the greatest linear diameter (GLD). Results: Aqueous endoglin, endostatin, FGF-α, HGF, and thrombospondin-2 levels were significantly higher in the nAMD group than those in the ARC group, whether before or after two conbercept injections. In the nAMD group, baseline thrombospondin-2 was positively correlated with GLD. Baseline FGF-α, thrombospondin-2, and VEGF-A were positively correlated with MRT-3 mm. After two conbercept injections, endostatin levels were positively correlated with VEGF-A. Conclusions: Endoglin, endostatin, FGF-α, HGF, and thrombospondin-2 may participate in the pathogenesis of nAMD.