Endo-5-Norbornene-2, 3-dimethanol-promoted asymmetric Heck/Suzuki cascade reaction of N-(2-bromophenyl)acrylamides. Issue 20 (31st August 2022)

• Record Type: Journal Article
• Authors: Chen, Ming; Xu, Xing-Xing; Wang, Xucai; Ren, Zhi-Hui; Guan, Zheng-Hui
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 20(2022)
• Page Start: 5557
• Page End: 5563
• Publication Date: 2022-08-31
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00998f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An endo -5-norbornene-2, 3-dimethanol-promoted highly enantioselective palladium-catalyzed Heck/Suzuki cascade reaction of N -(2-bromophenyl)acrylamides has been developed. Abstract : A highly enantioselective palladium-catalyzed Heck/Suzuki cascade reaction of N -(2-bromophenyl)acrylamides has been developed. The key to the success of this transformation was found to be the endo -5-norbornene-2, 3-dimethanol helping prevent transmetalation of the aryl-palladium complex. The reaction was shown to tolerate a wide range of functional groups and provide straightforward access to an array of oxindoles with excellent ee values.