Transition metal-free approach for late-stage benzylic C(sp3)–H etherifications and esterifications. Issue 81 (23rd September 2022)

• Record Type: Journal Article
• Authors: Zhang, Yu; Sahoo, Prakash Kumar; Ren, Peng; Qin, Yuman; Cauwenbergh, Robin; Nimmegeers, Philippe; SivaRaman, Gandhi; Van Passel, Steven; Guidetti, Andrea; Das, Shoubhik
• Is Part Of: Chemical communications. Volume 58:Issue 81(2022)
• Page Start: 11454
• Page End: 11457
• Publication Date: 2022-09-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc02661a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Herein, we report a transition metal-free approach for the regioselective functionalisation of benzylic C(sp 3 )–H bonds using alcohols and carboxylic acids as the nucleophiles. Late stage functionalization has been done with complex drug molecules. Abstract : We report a transition metal-free approach for the regioselective functionalization of benzylic C(sp 3 )–H bonds using alcohols and carboxylic acids as the nucleophiles. This straightforward and general route has provided various benzylic ethers and esters, including twelve pharmaceutically relevant compounds.