Synthesis of Novel 9, 9-Dimethyl-8, 12-Dihydro-9H-chromeno[3, 2-e] [1, 2, 4] triazolo[1, 5-c]pyrimidin-11(10H)-one derivatives. (August 2014)

• Record Type: Journal Article
• Authors: Wang, Zhong-Xia; Li, Bei; Xing, Zheng; Chen, Li-Zhuang; Han, Guang-Fan
• Is Part Of: Journal of chemical research. Volume 38:Number 8(2014)
• Page Start: 480
• Page End: 485
• Publication Date: 2014-08
• Subjects: chromeno[3, 2-e][1, 2, 4]triazolo[1, 5-c]pyrimidine-11(10H)-one -- formimidate -- chromeno[2, 3-d]pyrimidine; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751914X14053476598397
• Languages: English
• ISSNs: 1747-5198

Abstract

Novel 9, 9-dimethyl-8, 12-dihydro-9 H -chromeno[3, 2- e ][1, 2, 4]triazolo[1, 5- c ]pyrimidin-11(10 H )-one derivatives were synthesised by the reactions of triethyl orthoformate or aromatic aldehydes with chromeno[2, 3- d ]pyrimidine derivatives, which were prepared by the reactions of hydrazine monohydrate and formimidate derivatives. Formimidate were synthesised by the reactions of 2-amino-7, 7-dimethyl-5-oxo-4-aryl-5, 6, 7, 8-tetrahydro-4 H -chromene-3-carbonitrile derivatives and triethyl orthoformate. The structures of 12-(4-methoxyphenyl)-9, 9-dimethyl-8, 12-dihydro-9 H -chromeno[3, 2- e ][1, 2, 4]triazolo[1, 5- c ] pyrimidin-11(10 H )-one was determined by single crystal X-ray diffraction analysis.