A Concise Synthesis of (±)-Methoxyfumimycin Ethyl Ester. (June 2014)

• Record Type: Journal Article
• Authors: Zhou, Zhiwang; Hu, Yu; Wang, Bin; He, Xiaoru; Ren, Gang; Feng, Lihua
• Is Part Of: Journal of chemical research. Volume 38:Number 6(2014)
• Page Start: 378
• Page End: 380
• Publication Date: 2014-06
• Subjects: fumimycin -- (±)-methoxyfumimycin ethyl ester -- peptide deformylase inhibitors -- Friedel–Crafts alkylation; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751914X14011142030158
• Languages: English
• ISSNs: 1747-5198

Abstract

The protecting-group-free synthesis of (±)-methoxyfumimycin ethyl ester, a potential bacterial peptide deformylase (PDF) inhibitor, is reported. The synthetic approach features a tandem Friedel–Crafts alkylation/lactonisation access as a key reaction to generate α, α-disubstituted amino acid unit.