Heterogeneous Copper-Catalysed Cascade Reactions of 2-Bromobenzamides with β-Keto Esters Leading to Isoquinolin-1(2H)-One Derivatives. (October 2014)

• Record Type: Journal Article
• Authors: Zhao, Hong; Wu, Yichao; Wei, Tin; Cai, Mingzhong
• Is Part Of: Journal of chemical research. Volume 38:Number 10(2014)
• Page Start: 634
• Page End: 638
• Publication Date: 2014-10
• Subjects: supported copper catalyst -- cascade reaction -- isoquinolin-1(2H)-one -- 2-bromobenzamide -- β-keto ester; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751914X14117512932816
• Languages: English
• ISSNs: 1747-5198

Abstract

The heterogeneous copper-catalysed cascade reaction of 2-bromobenzamides with β-keto esters was achieved in dioxane at 80 °C in the presence of the MCM-41-immobilised bidentate nitrogen copper(I) complex [MCM-41-2N-CuI] with Cs2 CO3 as base, affording a variety of isoquinolin-1(2 H )-one derivatives in moderate to good yields. This heterogeneous copper catalyst can be recovered by a simple filtration and reused 10 times without significant loss of activity.