Associations of exposure to perfluoroalkyl substances with serum uric acid change and hyperuricemia among Chinese women: Results from a longitudinal study. (December 2022)

• Record Type: Journal Article
• Authors: Feng, Yue; Fu, Ming; Guan, Xin; Wang, Chenming; Meng, Hua; Zhou, Yuhan; He, Meian; Guo, Huan
• Is Part Of: Chemosphere. Volume 308:Part 3(2022)
• Publication Date: 2022-12
• Subjects: Perfluoroalkyl substance -- Serum uric acid -- Hyperuricemia -- Cohort study -- Quantile g-computation approach; CI confidence interval -- DAG directed acyclic graph -- DFTJ Dongfeng-Tongji -- DMC Dongfeng Motor Corporation -- eGFR estimated glomerular filtration rate -- HNF hepatocyte nuclear factor -- INT inverse-normal transformed -- LOD limit of detection -- OAT organic anion transporter -- OR odds ratio -- PFAS perfluoroalkyl substance -- PFDA perfluorodecanoic acid -- PFHpA perfluoroheptanoic acid -- PFHxS perfluorohexane sulfonic acid -- PFNA perfluorononanoic acid -- PFOA perfluorooctanoic acid -- PFOS perfluorooctane sulfonic acid -- SD standard deviation -- UA uric acid -- URAT urate anion transporter -- WQS weighted quantile sum regression; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.136438
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Background: Cross-sectional studies have reported associations of perfluorooctanoic acid (PFOA) with concurrent serum uric acid (UA) levels. However, the prospective associations of other commonly detected perfluoroalkyl substances (PFASs) with serum UA and hyperuricemia remain unclear. Methods: A total of 654 females from the Dongfeng-Tongji cohort, who were followed up from 2008 to 2018, were included in this study. We measured their baseline plasma concentrations of six PFASs [including perfluorooctane sulfonic acid (PFOS), PFOA, perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDA), and perfluoroheptanoic acid (PFHpA)], as well as their serum UA levels at both baseline and follow-up visits. General linear and logistic regression models were constructed to explore the associations of each PFAS with annual change of serum UA and incident hyperuricemia. Mixture effects of PFASs were further assessed by using the quantile g-computation approach. Results: Compared to participants with low PFNA exposure (≤50 th ), those with high PFNA exposure (>75 th ) had significantly increased annual increment of serum UA [β(95%CI) = 2.58 (0.60, 4.55)]. No significant associations of PFOS, PFOA, PFDA, PFHxS, or PFHpA with serum UA change were observed. Besides, females with high PFOA or PFHpA (>75 th ) exposure had higher incident risk of hyperuricemia than those with low exposure (<50 th ) [OR (95%CI) = 1.94 (1.00, 3.76) and 1.86 (1.03, 3.36), respectively]. No significant associations of PFOS, PFNA, PFDA, and PFHxS with hyperuricemia risk were observed. Quantile g-computation approach didn't find significant effects of PFAS co-exposure on serum UA change or hyperuricemia incidence. Conclusions: Our findings suggested exposure to PFASs as a risk factor for hyperuricemia and shed light on hyperuricemia prevention for elderly females. Graphical abstract: Image 1 Highlights: Prospective associations of PFASs with hyperuricemia risk remain largely unknown. PFNA was positively associated with annual increment of serum UA. PFOA and PFHpA were significantly associated with increased risk of hyperuricemia.