Influence of co-exposure to sulfamethazine on the toxicity and bioaccumulation kinetics of chlorpyrifos in zebrafish (Danio rerio). (December 2022)

• Record Type: Journal Article
• Authors: Jiang, Jiangong; He, Bingying; Liu, Xueke; Liu, Donghui; Zhou, Zhiqiang; Wang, Peng
• Is Part Of: Chemosphere. Volume 308:Part 2(2022)
• Publication Date: 2022-12
• Subjects: Chlorpyrifos -- Sulfamethazine -- Combined toxicity -- Bioaccumulation kinetic; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.136317
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Pesticides and antibiotics are frequently present in aquatic environment which may pose potential risks to aquatic organisms. However, the interaction of pesticides and antibiotics in co-exposure model remains unclear. Here, the effects of the co-exposure of sulfamethazine (SMZ) on the toxicity and bioaccumulation of the organophosphorus insecticide chlorpyrifos (CPF) in zebrafish ( Danio rerio ) were explored. The 96-h LC50 of chlorpyrifos to zebrafish was 1.36 mg/L and sulfamethazine at 1 mg/L slightly increased the acute toxicity with the 96-h LC50 of 1.20 mg/L which was not significant. The 30-day co-exposure of chlorpyrifos with sulfamethazine at 1 mg/L aggravated the oxidative stress, decreased CarE and AChE activity, and increased CYP450 activity significantly. Furthermore, the co-exposure reduced the accumulation of chlorpyrifos and sulfamethazine while prolonged their depuration duration. The results demonstrated the exposure risk of chlorpyrifos to zebrafish may be enhanced in the presence of sulfamethazine. Graphical abstract: Image 1 Highlights: Co-exposure to SMZ slightly alter acute toxicity of CPF to D. rerio. A 30-day co-exposure to SMZ aggravated oxidative stress of CPF to D. rerio. Co-exposure to SMZ stimulated CYP450 than SMZ or CPF alone. Co-exposure to SMZ prolonged the depuration of CPF in D. rerio tissues.