Does sports participation increase risk in patients with long QT syndrome? Results from a large French cohort . Issue 10 (11th August 2022)

• Record Type: Journal Article
• Authors: Davydoff, Caroline; Andorin, Antoine; Minois, Damien; Arnaud, Marine; Minier, Mathilde; Sacher, Frédéric; Martins, Raphael; Clementy, Nicolas; Gourraud, Jean Baptiste; Probst, Vincent
• Is Part Of: Europace. Volume 24:Issue 10(2022)
• Page Start: 1675
• Page End: 1683
• Publication Date: 2022-08-11
• Subjects: Long QT syndrome -- Sport; Arrhythmia -- Treatment -- Periodicals; Cardiac pacing -- Periodicals; Catheter ablation -- Periodicals; Heart -- Physiology -- Periodicals; Electrophysiology -- Periodicals; 617.4120645
• DOI: 10.1093/europace/euac047
• Languages: English
• ISSNs: 1099-5129

Abstract

Abstract: Aims: Sports practice, especially in competition, is usually restrained in patients diagnosed with long QT syndrome (LQTS). Although data are scarce, a low incidence of cardiac arrhythmic events (CAEs) during sports practice is reported. We aim to evaluate the incidence of CAE during sports practice in LQTS patients. Methods and results: All consecutive patients above 18 years of age diagnosed with LQTS and prospectively followed at the referral centre for inherited arrhythmia syndrome received a survey to retrospectively assess their sports practice prior to and after the diagnosis of LQTS. Two hundred and forty-six patients were included (57% females). The median age was 43 years, and the median QTc was 457 ms (428; 482). Patients reported a total of 4092 years [1376 (34%) after diagnosis] of sports practice: 2905 (77%) [1138 (39%) after diagnosis] years of leisure practice and 1187 (23%) [238 (20%) after diagnosis] years of competitive practice. One hundred and eighty (73%) patients practiced sport prior to the diagnosis of LQTS and 170 (69%) after. Prior to the diagnosis, four (2%) patients presented a CAE during leisure sports practice and one during competition. After diagnosis, only one patient presented a CAE, appropriately treated by an implantable cardioverter defibrillator discharge, in the context of beta-blocker non-compliance. The CAE event rate was 0.0007 events/year in the 1376 years of total sports practice after the diagnosis of LQTS. Conclusion: After the diagnosis of LQTS, the occurrence of CAE is very low during sports practice, even in competitive practice. There was no CAE in patients properly treated with beta-blocker therapy with good compliance. Graphical Abstract: Graphical Abstract Overview of cardiac arrhythmic events according to sport practice among Long QT syndrome patients.