Individual, Household, and Community Drivers of Dengue Virus Infection Risk in Kamphaeng Phet Province, Thailand . (4th May 2022)

• Record Type: Journal Article
• Authors: Ribeiro dos Santos, Gabriel; Buddhari, Darunee; Iamsirithaworn, Sopon; Khampaen, Direk; Ponlawat, Alongkot; Fansiri, Thanyalak; Farmer, Aaron; Fernandez, Stefan; Thomas, Stephen; Rodriguez Barraquer, Isabel; Srikiatkhachorn, Anon; Huang, Angkana T; Cummings, Derek A T; Endy, Timothy; Rothman, Alan L; Salje, Henrik; Anderson, Kathryn B
• Is Part Of: Journal of infectious diseases. Volume 226:Number 8(2022)
• Page Start: 1348
• Page End: 1356
• Publication Date: 2022-05-04
• Subjects: Dengue virus -- serology -- force of infection -- drivers of transmission; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiac177
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Dengue virus (DENV) often circulates endemically. In such settings with high levels of transmission, it remains unclear whether there are risk factors that alter individual infection risk. Methods: We tested blood taken from individuals living in multigenerational households in Kamphaeng Phet province, Thailand for DENV antibodies (N = 2364, mean age 31 years). Seropositivity ranged from 45.4% among those 1–5 years old to 99.5% for those >30 years. Using spatially explicit catalytic models, we estimated that 11.8% of the susceptible population gets infected annually. Results: We found that 37.5% of the variance in seropositivity was explained by unmeasured household-level effects with only 4.2% explained by spatial differences between households. The serostatus of individuals from the same household remained significantly correlated even when separated by up to 15 years in age. Conclusions: These findings show that despite highly endemic transmission, persistent differences in infection risk exist across households, the reasons for which remain unclear. Abstract : We explored the drivers of dengue infection in an endemic setting testing blood taken from multigenerational households and looking for antibodies against dengue virus. We showed that most of the variance in seropositivity was explained by unmeasured house-level effects.