Successful Treatment of a Reinfected Liver Graft Because of Receipt of a HCV-Positive Kidney. Issue 3 (16th March 2020)

• Record Type: Journal Article
• Authors: Azhari, Hassan; Tibbles, Lee Anne; Burak, Kelly W.; Congly, Stephen E.
• Is Part Of: ACG Case Reports Journal. Volume 7:Issue 3(2020)
• Page Start: e00341
• Publication Date: 2020-03-16
• DOI: 10.14309/crj.0000000000000341
• Languages: English
• ISSNs: 2326-3253

Abstract

ABSTRACT: Transplantation of hepatitis C virus (HCV)-positive organs has undergone a paradigm shift because of the advent of direct-acting antivirals. We present the case of a 57-year-old man successfully treated initially with pegylated interferon and ribavirin after HCV recurrence postliver transplantation. He subsequently developed end-stage renal disease and received a genotype 1a HCV-positive kidney transplant. A 12-week course of ledipasvir/sofosbuvir and low-dose ribavirin was initiated and sustained virologic response was achieved. This constitutes the first reported case of a patient successfully treated for HCV a second time after receiving an HCV-positive organ.