Acute Liver Injury due to Severe Epstein-Barr Virus Infection. Issue 2 (24th February 2020)

• Record Type: Journal Article
• Authors: Shah, Jamil; Lingiah, Vivek; Pyrsopoulos, Nikolaos; Galan, Mark
• Is Part Of: ACG Case Reports Journal. Volume 7:Issue 2(2020)
• Page Start: e00325
• Publication Date: 2020-02-24
• DOI: 10.14309/crj.0000000000000325
• Languages: English
• ISSNs: 2326-3253

Abstract

ABSTRACT: Epstein-Barr virus (EBV) is a widely dispersed herpesvirus, transferred through close personal contact between susceptible individuals and asymptomatic shedders of the virus. The liver is often affected, and involvement is usually subclinical and self-limited. However, immunocompromised patients and, more rarely, immunocompetent individuals can develop a severe and potentially fatal acute liver injury. To differentiate EBV hepatitis from other conditions, such as autoimmune hepatitis, lymphoproliferative disorders, and drug-induced liver injury, correlation with clinical history, laboratory findings, and histopathologic features is crucial. We report a unique case of a man who developed acute liver injury from a severe EBV infection.