The "Far Left" of the Morphologic Spectrum of Ovarian High-grade Serous Carcinoma: Case Report of a Purely Noninvasive High-grade Serous Carcinoma Mimicking an Ovarian Serous Borderline Tumor. (9th March 2021)

• Record Type: Journal Article
• Authors: Katsakhyan, Levon; Baraban, Ezra G.; Dumoff, Kimberly L.; Burger, Robert A.; Parikh, Rupal; Cooper, Kumarasen
• Is Part Of: International journal of gynecological pathology. Volume 40:Number 2(2021)
• Page Start: 175
• Page End: 179
• Publication Date: 2021-03-09
• Subjects: HGSC -- High-grade serous carcinoma -- Noninvasive ovarian high-grade serous carcinoma -- p53 signature -- serous borderline tumor; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000668
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : High-grade serous carcinoma has a variety of different growth patterns, but is typically easily recognizable to pathologists and rarely confused with serous borderline tumors. We report a case of a 71-yr-old woman with a unilateral 5.1 cm ovarian cyst with small papillary projections on contrast-enhanced magnetic resonance imaging of the pelvis. Histologic examination showed a noninvasive papillary neoplasm with hierarchical branching and epithelial proliferation, and thus, at low magnification, bearing a striking resemblance to a serous borderline tumor. However, a more careful examination demonstrated high-grade cytologic features, nuclear pleomorphism, and abundant mitotic activity, suggestive of high-grade serous carcinoma. The morphology and immunohistochemical profile of this lesion is consistent with a rare, purely noninvasive growth pattern of high-grade serous carcinoma. This lesion represents the "far left" of the high-grade ovarian serous carcinoma morphologic spectrum and can mimic a serous borderline tumor.