Back Cover: Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action (Angew. Chem. Int. Ed. 28/2021). Issue 28 (19th April 2021)

• Record Type: Journal Article
• Authors: Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio M.; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 28(2021)
• Page Start: 15660
• Page End: 15660
• Publication Date: 2021-04-19
• Subjects: antiparasitic agent -- drug discovery -- medicinal chemistry -- mode of action -- peptides; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202104896
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Leucinostatins are fascinating natural substances, with high potency against many pathogens, but their acute toxicity has prevented therapeutic use. Michael Adams, Rainer Riedl, and co‐workers demonstrate in the Research Article on page 15613 how these can be converted into synthetically more accessible and more selective antiprotozoal agents with broad efficacy and undetectable resistance.