Prediction of risk of falls based on handgrip strength in chronic liver disease patients living independently. Issue 7 (19th March 2019)

• Record Type: Journal Article
• Authors: Hiraoka, Atsushi; Tamura, Rumi; Oka, Misato; Izumoto, Hirofumi; Ueki, Hidetaro; Tsuruta, Miho; Yoshino, Takeaki; Ono, Atsushi; Aibiki, Toshihiko; Okudaira, Tomonari; Yamago, Hiroka; Suga, Yoshifumi; Iwasaki, Ryuichiro; Mori, Kenichiro; Miyata, Hideki; Tsubouchi, Eiji; Kishida, Masato; Ninomiya, Tomoyuki; Hirooka, Masashi; Abe, Masanori; Matsuura, Bunzo; Hiasa, Yoichi; Kino, Tsutae; Yamamoto, Kayo; Michitaka, Kojiro
• Is Part Of: Hepatology research. Volume 49:Issue 7(2019)
• Page Start: 823
• Page End: 829
• Publication Date: 2019-03-19
• Subjects: chronic liver disease -- cognitive function -- falling -- handgrip strength -- sarcopenia; Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.13322
• Languages: English
• ISSNs: 1386-6346

Abstract

Abstract : Aim: Falling is known to be associated with cognitive function. We evaluated the relationship between muscle function and falls in patients with chronic liver disease (CLD). Methods: We enrolled 100 sequential CLD patients without dementia who were admitted to our institution for scheduled treatment from July 2017 to May 2018 (age 71.0 ± 10.2 years; 76 men). All subjects were self‐reliant in regard to activities of daily living. On admission, handgrip strength was determined and falls within 1 month of admission were noted. For determining handgrip strength decline (HSD), previously reported values were used (men, <26 kg; women, <18 kg). The relationship between HSD and falls in CLD patients was evaluated in a retrospective manner. Results: Thirty‐two patients had chronic hepatitis and 49 had liver cirrhosis (LC) Child–Pugh A, 17 had LC Child–Pugh B, and 2 had LC Child–Pugh C. Twelve (12.0%) had a history of falling, including 8 (26.7%) of 30 with and 4 (5.7%) of 70 without HSD ( P = 0.006). The cut‐off value for age in relationship to falling was 69.0 years old (area under the receiver operating characteristic curve, 0.668; 95% confidence interval, 0.514–0.821). A fall during hospitalization was noted more often in patients with a history of falling than in those without (16.7% [2/12] vs. 2.3% [2/88], P = 0.018). Conclusion: In CLD patients, the presence of HSD and older age might be independent risk factors for predicting a fall. Assessment of handgrip strength could be an effective clinical tool for easily assessing the risk of falling, especially in elderly CLD patients.