Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery. (25th February 2021)

• Record Type: Journal Article
• Authors: Li, Haidong; Kim, Dayeh; Yao, Qichao; Ge, Haoying; Chung, Jeewon; Fan, Jiangli; Wang, Jingyun; Peng, Xiaojun; Yoon, Juyoung
• Is Part Of: Angewandte Chemie. Volume 133:Number 32(2021)
• Page Start: 17408
• Page End: 17429
• Publication Date: 2021-02-25
• Subjects: enzyme activity -- image-guided surgery -- near-infrared activation -- tumors; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202009796
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumor genesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme‐reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image‐guided intraoperative surgeries with high signal‐to‐noise ratios. In this review, we mainly summarize the latest advancements in enzyme‐reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future. Abstract : Near‐infrared enzyme‐activatable fluorescent probes have been considered to be an effective tool for the diagnosis and treatment of tumors. This review focuses on the design strategy of enzyme‐activated fluorescent probes, the development of biological applications and new multifunctional probes as well as the direction of clinical transformation.