Prognostic implications of Anemia in patients with acute heart failure in emergency departments. ANEM‐AHF Study. Issue 4 (5th January 2021)

• Record Type: Journal Article
• Authors: de los Ángeles Fernández‐Rodríguez, M.; Prieto‐García, B.; Vázquez‐Álvarez, J.; Jacob, J.; Gil, V.; Miró, O.; Llorens, P.; Martín‐Sánchez, F. J.; Alquézar‐Arbé, A.; Rodríguez‐Adrada, E.; Romero‐Pareja, R.; López‐Diez, P.; Herrero‐Puente, P.
• Other Names: Fuentes Marta investigator.; Gil Cristina investigator.; Alonso Héctor investigator.; Pérez‐Llantada Enrique investigator.; Martín‐Sánchez Francisco Javier investigator.; García Guillermo Llopis investigator.; Cadenas Mar Suárez investigator.; Miró Òscar investigator.; Gil Víctor investigator.; Escoda Rosa investigator.; Xipell Carolina investigator.; Sánchez Carolina investigator.; Pérez‐Durá María José investigator.; Salvo Eva investigator.; Pavón José investigator.; Noval Antonio investigator.; Torres José Manuel investigator.; López‐Grima María Luisa investigator.; Valero Amparo investigator.; Juan María Ángeles investigator.; Aguirre Alfons investigator.; Pedragosa Maria Angels investigator.; Masó Silvia Mínguez investigator.; Alonso María Isabel investigator.; Ruiz Francisco investigator.; Franco José Miguel investigator.; Mecina Ana Belén investigator.; Tost Josep investigator.; Berenguer Marta investigator.; Donea Ruxandra investigator.; Ramón Susana Sánchez investigator.; Rodríguez Virginia Carbajosa investigator.; Piñera Pascual investigator.; Nicolás José Andrés Sánchez investigator.; Garate Raquel Torres investigator.; Alquézar‐Arbé Aitor investigator.; Rizzi Miguel Alberto investigator.; Herrera Sergio investigator.; Jacob Javier investigator.; Roset Alex investigator.; Cabello Irene investigator.; Haro Antonio investigator.; Richard Fernando investigator.; Pérez José María Álvarez investigator.; Diez María Pilar López investigator.; Puente Pablo Herrero investigator.; Álvarez Joaquín Vázquez investigator.; García Belén Prieto investigator.; García María García investigator.; González Marta Sánchez investigator.; Llorens Pere investigator.; Javaloyes Patricia investigator.; Marquina Víctor investigator.; Jiménez Inmaculada investigator.; Hernández Néstor investigator.; Brouzet Benjamín investigator.; Espinosa Begoña investigator.; Gil Adriana investigator.; Andueza Juan Antonio investigator.; Romero Rodolfo investigator.; Ruíz Martín investigator.; Calvache Roberto investigator.; Serralta María Teresa Lorca investigator.; Jave Luis Ernesto Calderón investigator.; Arriaga Beatriz Amores investigator.; Bergua Beatriz Sierra investigator.; Mojarro Enrique Martín investigator.; Jiménez Brigitte Silvana Alarcón investigator.; Bécquer LisetteTravería investigator.; Burillo Guillermo investigator.; García Lluís Llauger investigator.; LaSalle Gerard Corominas investigator.; Urbano Carmen Agüera investigator.; García Soto Ana Belén investigator.; Padial Elisa Delgado investigator.; Ferrer Ester Soy investigator.; Múñoz María Adroher investigator.; Garrido José Manuel investigator.; Gaya Rut investigator.; Bibiano Carlos investigator.; Mir María investigator.; Rodríguez Beatriz investigator.; Carballo José Luis investigator.; Rodríguez‐Adrada Esther investigator.; Miranda Belén Rodríguez investigator.; Martín Monika Vicente investigator.;
• Is Part Of: International journal of clinical practice. Volume 75:Issue 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-05
• Subjects: Clinical medicine -- Periodicals; Medicine -- Periodicals; 610.5
• DOI: 10.1111/ijcp.13712
• Languages: English
• ISSNs: 1368-5031

Abstract

Abstract: Introduction: The presence of anaemia leads to a worse prognosis in patients with heart failure (HF). There are few data on the impact of anaemia on mortality in patients with acute heart failure (AHF), and the studies available are mainly retrospective, and include hospitalised patients. Objective: Evaluate the role of anaemia on 30‐day and 1‐year mortality in patients with AHF attended in hospital emergency departments (HEDs). Methods: We performed a multicentre, observational study of prospective cohorts of patients with AHF. The study variables were: Anaemia (haemoglobin < 12g/dL in women and <13g/dL in men), mortality at 30 days and at 1 year, risk factors, comorbidity, functional impairment, basal functional grade for dyspnoea, chronic and acute treatment, clinical and analytical data of the episode, and patient destination. Statistical analysis: Bivariate analysis and survival analyses using Cox regression. Results: A total of 13 454 patients were included, 7662 (56.9%) of whom had anaemia. Those with anaemia were older, had more comorbidity, a worse functional status and New York Heart Association class, greater renal function impairment, and more hyponatraemia. The mortality was higher in patients with anaemia at 30 days and 1 year: 7.5% vs 10.7% ( P < .001) and 21.2% vs 31.4% ( P < .001), respectively. The crude and adjusted hazard ratios of anaemia for 30‐day mortality were: 1.46 (confidence interval [CI] 95% 1.30‐1.64); P < .001 and 1.20 (CI 95% 1.05‐1.38); P = .009, respectively, and 1.57 (CI 95% 1.47‐1.68) and 1.30 (CI 95% 1.20‐1.40) for mortality at 1 year. The weight of anaemia on mortality was different in each follow‐up period. Conclusions: Anaemia is an independent predictor of mortality at 30 days and 1 year in patients with AHF attended in HEDs. It is important to study the aetiology of AHF since adequate treatment would reduce mortality.