Copper‐Catalyzed Borylative Methylation of Alkyl Iodides with CO as the C1 Source: Advantaged by Faster Reaction of CuH over CuBpin. Issue 21 (16th April 2021)

• Record Type: Journal Article
• Authors: Wu, Fu‐Peng; Wu, Xiao‐Feng
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 21(2021)
• Page Start: 11730
• Page End: 11734
• Publication Date: 2021-04-16
• Subjects: alkyl iodides -- borylmethylation -- carbonylation -- copper boryl -- copper hydride; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202102197
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: CuH and CuBpin are versatile catalysts and intermediates in organic chemistry. However, studies that involve both CuH and CuBpin in the same reaction is still rarely reported due to their high reactivity. Now, a study on CuH‐ and CuBpin‐catalyzed borylative methylation of alkyl iodides with CO as the C1 source is reported. Various one carbon prolongated alkyl boranes (RCH2 Bpin and RCH(Bpin)2 ) were produced in moderate to good yields from the corresponding alkyl iodides (RI). In this cooperative system, CuH reacts with alkyl iodide faster than CuBpin. Abstract : A study on CuH‐ and CuBpin‐catalyzed borylative methylation of alkyl iodides with CO as the C1 source is reported. Various one carbon prolongated alkyl boranes (RCH2 Bpin and RCH(Bpin)2 ) were produced in moderate to good yields from the corresponding alkyl iodides (RI). In this cooperative system, CuH reacts with alkyl iodide faster than CuBpin.