Treatment with intravenous busulfan, melphalan, and etoposide followed by autologous stem cell transplantation in patients with non‐Hodgkin's lymphoma: a multicenter study from the consortium for improving survival of lymphoma. (23rd July 2020)

• Record Type: Journal Article
• Authors: Kim, Kyoung Ha; Kim, Won Seog; Kim, Seok Jin; Yoon, Dok Hyun; Suh, Cheolwon; Kang, Hye Jin; Choi, Chul Won; Lee, Ho Sup; Bae, Sung Hwa; Park, Jinny; Park, Eun Kyung; Kwak, Jae‐Yong; Lee, Mark Hong; Kang, Byung Woog; Park, Sung‐Kyu; Won, Jong‐Ho
• Is Part Of: Transplant international. Volume 33:Number 10(2020)
• Page Start: 1211
• Page End: 1219
• Publication Date: 2020-07-23
• Subjects: autologous stem cell transplantation; Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.13664
• Languages: English
• ISSNs: 0934-0874

Abstract

Summary: Several high‐dose therapy (HDT) conditioning regimens have been used to treat non‐Hodgkin's lymphoma (NHL), such as bis‐chloroethylnitrosourea (BCNU)/etoposide/cytosine arabinoside/melphalan (BEAM), BCNU/etoposide/cytosine arabinoside/cyclophosphamide (BEAC), and cyclophosphamide/BCNU/etoposide (CBV). BCNU is an active drug in HDT of NHL, but the supply is limited in some countries, including Korea. Busulfan has been used in allogeneic and autologous stem cell transplantation (ASCT). This phase II study evaluated the efficacy of busulfan/melphalan/etoposide (BuME) as a conditioning regimen for HDT in relapsed or high‐risk NHL. The regimen consisted of intravenous busulfan (3.2 mg/kg/day) on days −8, −7, and −6, etoposide (400 mg/m 2 /day) on days −5 and −4, and melphalan (50 mg/m 2 /day) on days −3 and −2. A total of 46 patients were included in the study, with 36 (78.3%) achieving a complete response after ASCT. The 2‐year progression‐free survival (PFS) and overall survival (OS) rates for all patients were 46.7% (95% CI, 31.8–60.4%) and 63.7% (95% CI, 47.7–76.0%), respectively. There was no development of veno‐occlusive disease and no treatment‐related deaths within 100 days after ASCT. These results indicate that a BuME regimen is well‐tolerated and effective for patients with relapsed or high‐risk NHL, and may be comparable to some previously used regimens. This regimen may be useful as a substitute for BCNU‐containing regimens.