Evaluation of antibiotic prophylaxis for gastrointestinal surgeries in a teaching hospital: An interventional pre–post study. Issue 12 (December 2022)

• Record Type: Journal Article
• Authors: Elyasi, Sepideh; Fattahi Masum, Asiyeh; Bahreyni, Amirhossein; Samani, Seyed Sattar; Atamanesh, Ahmad; Abdollahi, Abbas; Mousavi, Maryam
• Is Part Of: Journal of perioperative practice. Volume 32:Issue 12(2022)
• Page Start: 354
• Page End: 360
• Publication Date: 2022-12
• Subjects: Antibiotic prophylaxis / Gastrointestinal surgery / Surgical site infection / Drug use evaluation / Guideline; Operating room nursing -- Periodicals; 617.9192
• DOI: 10.1177/1750458919825583
• Languages: English
• ISSNs: 2515-7949

Abstract

Surgical site infections are related to a high morbidity, mortality and healthcare costs. Despite ample evidence demonstrating the effectiveness of antimicrobials to prevent surgical site infections, inappropriate timing, antibiotic selection and excessive continuation of antibiotics are common in practice. In this study, we compare the appropriateness of antibiotic prophylaxis in gastrointestinal surgery, before and after an evidence-based guideline implementation. One hundred patients were evaluated in each group. The implementation of the guideline resulted in significant reduction of incorrect use of antibiotics from 55% to 18% (P = 0.002). It also reduced duration of prophylactic antibiotics (43% vs. 23%, P = 0.025). Inappropriate doses diminished but not significantly (8% vs. 5%, P = 0.321). Based on our results, in more than half of of these cases patients received incorrect antibiotic prophylaxis regimens for gastrointestinal surgery in this hospital. Local guideline implementation can result in reduction of antibiotic use, dose and duration errors.