The long-term outcome of New Zealand Maori and Pacific Island children diagnosed with childhood onset lupus nephritis. (November 2022)

• Record Type: Journal Article
• Authors: Concannon, Anthony; Wong, William; Han, Dug Yeo
• Is Part Of: Lupus. Volume 31:Number 13(2022)
• Page Start: 1671
• Page End: 1678
• Publication Date: 2022-11
• Subjects: Nephritis -- renal lupus -- systemic lupus erythematosus; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/09612033221128437
• Languages: English
• ISSNs: 0961-2033

Abstract

Objective: To determine the long-term outcome of Maori and Pacific Island children diagnosed with childhood onset lupus nephritis. Method: A chart review was conducted of children diagnosed with biopsy proven lupus nephritis seen by the Starship Hospital and Kidz First paediatric rheumatology and/or Starship renal services between January 1992 and January 2018. Baseline and follow-up kidney histology, adherence and response to therapy including partial or full renal remission, refractory disease, end-stage kidney disease (ESKD) and mortality were determined. Results: In a New Zealand cohort of 42 with childhood onset lupus nephritis, Maori and Pacific Island children were significantly more likely to develop class 4 lupus nephritis (RR (95% CI), 11.3 (3.84–49.9), p < 0.0001), demonstrate medication nonadherence (RR (95% CI) 12.4 (3.48–85.7), p < 0.0001) and experience end stage kidney disease (RR (95% CI) 15.7 (2.97–389.3), p = 0.0003) and mortality (RR (95% CI) 11.1 (1.91–280.1), p = 0.005) compared to non-Maori and Pacific Island children. In addition, Maori children with childhood onset lupus nephritis developed chronic histological changes significantly more rapidly than Pacific or Asian children ( p = 0.038). Conclusion: Lupus nephritis is more common among Maori and Pacific Island children in New Zealand associated with a significant incidence of end stage kidney disease and mortality, with some Maori children developing rapid histologic disease progression.