Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer. Issue 2 (10th March 2018)

• Record Type: Journal Article
• Authors: Babli, Saleha; Payne, Richard J. ; Mitmaker, Elliot; Rivera, Juan
• Is Part Of: European thyroid journal. Volume 7:Issue 2(2018)
• Page Start: 95
• Page End: 101
• Publication Date: 2018-03-10
• Subjects: Papillary thyroid cancer -- Chronic lymphocytic thyroiditis -- Disease persistence; Thyroid gland -- Diseases -- Periodicals; Thyroid Diseases -- Periodicals; 612.44
• DOI: 10.1159/000486367
• Languages: English
• ISSNs: 2235-0640

Abstract

Abstract : Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy. Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC. Design: Retrospective study. Patients: All patients with PTC who had been followed by the 2 co-investigators (Juan Rivera and Richard J. Payne) between 2006 and 2011 were included. Results: CLT was present in 35% (166) of the included patients and was associated with a higher proportion of patients with TNM stage I ( p = 0.027) and fewer patients with persistent disease ( p = 0.014) in comparison with the PTC-only group. Analysis of the data based on age (<45 or >45 years) revealed that in the older group, the presence of CLT was associated with fewer patients with persistent disease ( p = 0.03) and capsular invasion ( p = 0.05). However, in patients <45 years of age, the presence of CLT was associated with more capsular invasion ( p = 0.003) and extrathyroidal extension ( p = 0.004) compared with the PTC-only group. Conclusions: CLT in patients with PTC was associated with lower-stage disease and less disease persistence in patients >45 years of age. In patients <45 years, the presence of CLT appeared to be associated with unfavorable pathological features.